Nahalat Yitzhak is a neighborhood of Tel Aviv, Israel.
Nahalat Yitzhak was founded in 1925, east of the Ayalon River and the Ayalon Highway, by a group of Jews who came from Kaunas. Nahalat Yitzhak is named after Rabbi Isaac (Yitzhak) Elchanan Spector, chief rabbi of Kaunas, who wrote a book called "River of Isaac".
In 1931, the neighborhood had 36 houses and a population of 134 people. It was established on the border of the German Colony Sarona, adjacent to the Borochov neighborhood, the first neighborhood of Givatayim. At the beginning it was a farming neighborhood of homesteads, and later a number of industrial plants, were built on the neighborhood's outskirts, among them "Tara Dairies", "Yitzhar" factory (the area were Tel Aviv Towers built), number of flour mills and more.
In 1958, the interior minister annexed the neighborhood to Givatayim, but the Supreme Court reversed the decision after it became clear that the position of opponents of the annexation were not heard, and the neighborhood remained in the jurisdiction of the Tel Aviv.